ABSTRACT
<p><b>OBJECTIVE</b>To introduce the methods for immediate reconstruction of tissue defects on eyelid caused by tumor excision.</p><p><b>METHODS</b>Single or combined local skin flaps were used to repair tissue defects on eyelids after tumor excision.</p><p><b>RESULTS</b>Since 1994, 216 patients (224 sides) were treated. All flaps survived with primary healing. 149 patients were followed up for 3 months to 10 years with satisfactory results. 2 patients with squamous cell carcinoma recurred and reoperated with local skin flap again.</p><p><b>CONCLUSIONS</b>It is a simple, safe, flexible and reliable method to immediately repair the tissue defects with local flaps on eyelid caused by tumor excision.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Young Adult , Blepharoplasty , Methods , Eyelid Neoplasms , General Surgery , Eyelids , General Surgery , Postoperative Complications , General Surgery , Plastic Surgery Procedures , Methods , Skin Transplantation , Surgical FlapsABSTRACT
<p><b>OBJECTIVE</b>To introduce the application of reverse dorsal radial flap in reconstruction of distal segment defect of thumb.</p><p><b>METHODS</b>From January 2004 to June 2007, 24 cases of soft tissue defect with exposed bone or tendon at the distal segment of thumb were involved. The flap size ranged from 2 cm x 2 cm to 3 cm x 4 cm.</p><p><b>RESULTS</b>Venous congestion happened in 3 cases with one case of partial necrosis at the distal end of the flap. All the other flaps survived completely. The follow-up period was 6 - 24 months. The appearance and function of the thumbs were satisfactory. The 2-point discrimination was 7 - 11 mm (mean 9.3 mm).</p><p><b>CONCLUSIONS</b>Reverse dorsal radial flap is a good option for reconstruction of distal segment defect of thumb.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Finger Injuries , General Surgery , Skin Transplantation , Methods , Soft Tissue Injuries , General Surgery , Surgical Flaps , Thumb , Wounds and InjuriesABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid.</p><p><b>METHODS</b>Immunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data.</p><p><b>RESULTS</b>The expression of TGF-betaR I were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus.</p><p><b>CONCLUSIONS</b>The results indicate that over-expression of TGF-betaR I, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This research may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.</p>